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Several members of the ADAM (a disintegrin and metalloproteinase) family possess α-secretase-like activity and three of them have been suggested as the α-secretase: ADAM9, ADAM10, and ADAM17.Like APP, they are also type-I transmembrane proteins.These studies strongly suggest that ADAM10 is the constitutive α-secretase that is active at the cell surface, though there may be some functional redundancy in α-cleavage among the ADAM family.

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AD is characterized in patients by an inexorably progressing dementia.APP knockout mice are viable and fertile, showing a relatively subtle abnormal phenotype [Although APP has been the subject of much study since its identification, its physiological function remains largely undetermined.A role for APP has been suggested in neurite outgrowth and synaptogenesis, neuronal protein trafficking along the axon, transmembrane signal transduction, cell adhesion, calcium metabolism, etc, all requiring additional ) during its intracellular trafficking and these APP metabolites mediate various and sometimes adverse functions.Indeed, several APP ligands have been identified, such as Aβ [].Indeed, further study in cell cultures demonstrated that APP can form homodimers and heterodimers in a trans-dimerization manner with other APP family members and that such dimerization promotes intercellular adhesion [].

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