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Watkins has worked as an actress, appearing in Hype Williams' 1999 film Belly.
She also appeared in an episode of Living Single, the first time guest-starring along with her bandmates and another time without them.
In addition, she has been a featured vocalist on such songs as: "Ghetto Love" with Da Brat, "Changes" with Society of Soul, "He Say She Say" with Keith Sweat, "Different Times" with Raphael Saadiq and "Be Somebody" with Paula Cole.
Watkins has appeared on a song by her TLC bandmate Rozonda Thomas, entitled "Gameproof".
Watkins has made a guest appearance as Pam Grier in one episode of the Adult Swim series Black Dynamite.
Initially withholding details of her ailment from others, Watkins went public with her struggle with sickle cell anemia in 1996 and later became one of the spokespersons for Sickle Cell Disease Association of America.
Watkins married rapper Mack 10 (Dedrick D-Mon Rolison) in 2000, and the couple had a daughter named Chase Anela the same year. Watkins was diagnosed with a brain tumor in 2006; she underwent surgery to have the tumor removed and underwent several years of physical therapy for full recovery.She has won four Grammy Awards for her work with TLC. Crystal Jones held auditions for a singing group and chose Watkins, and Lisa "Left Eye" Lopes.The group eventually attracted the attention of Perri "Pebbles" Reid and her husband, Antonio "L. Jones was replaced with Rozonda "Chilli" Thomas and the group was signed in 1991 as TLC.In 2002, she was hospitalized for four months due to a flare-up of sickle-cell anemia.She has stated that her faith in God and her optimism have helped her stay free from the more serious effects of sickle-cell disease.