Vickie tern s estrogen hormones stories

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The most commonly used antiandrogens in transgender women are cyproterone acetate, spironolactone, and Gn RH analogues.

Today, high doses of a less potent estrogen – estradiol, which is endogenous to the human body, rather than the riskier ethinylestradiol and conjugated estrogens used in the past – are recommended during the first ten or so years of HRT, with or without an orchiectomy or sex reassignment. Androgens, such as testosterone and dihydrotestosterone (DHT), are the major sex hormones in men, and are responsible for the development and maintenance of male secondary sexual characteristics, such as a deep voice, broad shoulders, and a masculine pattern of hair, muscle, and fat distribution.Therefore, patients with relative contraindications may start at low dosages and increase gradually.Inducers of CYP3A4 and other cytochrome P450 enzymes can reduce the effects of MTF HRT.In addition, they stimulate sex drive and the frequency of spontaneous erections and are responsible for acne, body odor, and male-pattern scalp hair loss.Androgens act by binding to and activating the androgen receptor (AR), their biological target in the body.

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