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The external genital organ of the newborn baby was normal.

The C-banding showed the Y chromosome contained two centromeres and two heterochromatin blocks (Fig. The Array-based comparative genomic hybridization (a CGH) using a high density Cyto Scan V5 was applied to detect genomic aberrations.

[2006] [8] who postulated that the isodicentric Y chromosome was stabilized early during gametogenesis in the father.

The stability of dicentrics may result from inactivation of one of the centromeres [2], or due to presence of a very small distance between two active centromeres and thus behaving as monocentric [12].

The mosaicism may be more or less complex depending on its meiotic or post—zygotic origin and on its mitotic stability, and it usually includes of a 45, X cell line.

Patients carrying a dicentric Y chromosome have a wide range of somatic, genital, and gonadal phenotypic manifestations, depending on the structure of the dicentric Y chromosome, the Yp and Yq breakpoints, and the types of mosaicism [5].

The result of m BAND and FISH analysis show the abnormal Y chromosome was composed of the two intact Y chromosomes fused at the second pseudo-autosomal region of Yq (Fig. c a CGH shows the duplication of the Y chromosome Prenatal detection of an idic (Yp) or (Yq) often poses significant counseling dilemma given many cases are presented in the mosaic form and have highly variable clinical features.

Most (approximately 90 %) of dicentric Y chromosomes are present in mosaic form.

Another unique feature for our case is that the breakpoint occurred at Yq11.23 pseudo-autosomal region 2 (PAR-2) very close to the telomere.

Pseudo-autosomal regions are also hot-spots for genetic recombination and gene conversion [10].

Here we report a case of de novo isodicentric (Yq12) in the fetus.

The fusion occurred at Yq pseudo-autosomal region very close the telomere and resulted in duplication of Y chromosomes. A 36-year-old Taiwanese woman, gravida 1 para 0, underwent amniocentesis at the 18th week of gestation due to advanced maternal age.

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